Hematology Profile of Pregnant Women in Trimester III with Covid-19


  • Ririn Handayani Universitas dr. Soebandi Jember
  • Ernawati Anggareni Universitas dr. Soebandi Jember
  • Nazmi Kamila Universitas dr. Soebandi Jember




women pregnant, covid-19, hematology


Women pregnant  classified  as  vulnerable  groups  because  of  changes  in  body  physiology  and  immune  response  mechanisms  in  their  bodies.  SARS-CoV-2  infection  in  pregnancy  stimulates  an  increase  in  the  expression  of  proinflammatory  cytokines,  namely  IL-6,  IL-12,  IL-1β, dan IFNγ which  can  damage  lung  organs.  The  purpose  of  this  study  was  to  look  at  the  hematological  profile  of  pregnant  women  with  COVID-19,  especially  in  the  third  trimester  as  an  effort  to  detect  the  severity  of  the  infection  experienced  by  the  mother.  This  study  was  a  quantitative  descriptive  study  with  a  retrospective  design  using  secondary  data  from  medical  records.  This  study  was  carried  out  at  dr.  Soebandi  Hospital  Jember,  medical  record  data  were  taken  from  January to  December  2021.  The  subjects  of  study  were  pregnant  women  in  the  third  trimester  with  COVID-19.  The  sampling  technique    total  sampling.  Method  of  analysis  in  this  study  used  a  frequency  distribution.  Results  of  the  study  showed  that  100%  of  pregnant  women  with  COVID-19  had  symptoms  of  cough,  runny  nose,  fever  and  shortness  of  breath.  Results  of  the  mother's  hematological  examination  showed  an  increase  in  leukocytes  (48%)  and  a  decrease  in  lymphocytes  (92%),  most  of  the  mothers  had  anemia  (76%),  there  was  a  decrease  in  platelets  (8%)  and  an  increase  in  platelets  (20%). In conclusion, they had  the  same  symptoms  as  patients  in  general,  including  cough,  runny  nose,  fever  to  shortness  of  breath,  an  increase  in  leukocytes  and  a  decrease  in  lymphocytes,  most  of  the  mothers  also  experience  anemia and  changes  to  abnormal  maternal  platelets  occur.

Author Biographies

Ririn Handayani, Universitas dr. Soebandi Jember

Midwifery Department

Ernawati Anggareni, Universitas dr. Soebandi Jember

Midwifery Department

Nazmi Kamila, Universitas dr. Soebandi Jember

Midwifery Department


Azab Azab Elsayed, Jbireal J.M., Albasha Mohamed Umar. (2020). Haematological Changes during Pregnancy: Insight into Anaemia, Leukocytosis, and Thrombocytopenia. East African Scholars International Journal of Medical Sciences; Vol-3, Iss-5; 185-192.

Christyani, Fenyta ; Padang, Astrid Fransisca. (2020). Transmisi Vertikal COVID 19 selama Kehamilan. CDK-290/ vol. 47 no. 9 th. 2020. http://www.cdkjournal.com/index.php/CDK/article/viewFile/1190/886

Dashraath P et al. (2020). Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. American journal of obstetrics and gynecology, 222(6), 521–531.

Hafi Nurinasari, Nurhasan Agung Prabowo, Asih Anggraeni, Syahrini Wisdayanti, Sri Sulistyowati. (2021). Profil Laboratorium Ibu Hamil dengan COVID-19 di Rumah Sakit UNS. SMedJour, 2021 ; 4 (2) : 83 - 87 doi: 10.13057/smj.v4i2. 49249

Huang, Glen., , Alex J. Kovalic , Christopher J. Graber. (2020). Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity. Emerg InfectDis.26(8):1839-1841 https://stacks.cdc.gov/view/cdc/91567

Jesenak, M., Brndiarova, M., Urbancikova, I., Rennerova, Z., Vojtkova, J., Bobcakova, A., Banovcin, P. (2020). Immune Parameters and COVID-19 Infection - Associations With Clinical Severity and Disease Prognosis. Frontiers in cellular and infection microbiology, 10, 364-364. doi: 10.3389/fcimb.2020.00364

Letícia S, Toledo DO, Nogueira LS, Carvalho G. (2020). COVID-19: Review and hematologic impact. Clin Chim Acta. 2020;510(January): 170–6. 7.

Liu L, Zheng Y, Cai L, Wu W, Tang S, Lu H et al., (2020a). Neutrophil tolymphocyte ratio, a critical predictor of disease severity in patients withCOVID-19, Original article, DOI: 10.1111/ijlh.1337, WILEY.P. 1- 9

Maharani, Puan. 2021. Tekan Angka Kematian Akibat Covid-19. https://www.dpr.go.id/berita/detail/id/34240/t/Puan+Maharani%3A+Tekan+Angka+Kematian+Ibu+Hamil+Akibat+Covid-19

Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, et al.(2020). Platelet gene expression and function in patients with COVID19. Blood. 2020;136(11):1317–29.

Martinellia I, Ferrazzib E, Ciavarella A, Errab R, Iurlarob E et al. (2020). Pulmonary Embolism in a Young Pregnant Woman with COVID-19. Thromb Res. 191: 36-37.

Mor G, Aldo P, Alvero A. (2017). The unique immunological and microbial aspects of pregnancy. Nature Rev Immunol. 2017;17(8):469-82. https://doi.org/10.1038/nri.2017.64

Nurdianto AR, Aryati, Mohammad GS, Mufasirin. (2019). Downregulates of icam1 expression in myometrium from pregnant rattus norvegicus infected with tachyzoite of toxoplasma gondii with hyperbaric oxygen therapy. Hang Tuah Medical Journal. 2019;17:77–83.

Nurdianto AR. (2020). Studi Klinis Infeksi COVID-19 pada Kehamilan dengan Insulin Dependent Diabetes Mellitus (IDDM). Jurnal Ilmiah Kedokteran Wijaya Kusuma 9(2) : 229-244, September 2020

Nurdianto, AR, Aryati, Suryokusumo MG, Mufasirin, Suwanti LT et al. (2020). Effects of Hyperbaric Oxygen Therapy on IL-17, Fetal Body Weight and Total Fetus in Pregnant Rattus Norvegicus Infected with Tachyzoite Toxoplasma Gondii. Systematic Reviews in Pharmacy. 2020; 11(3):628–34. 7.

Pradana AA, Casman C, Nur’aini N. (2020). Pengaruh Kebijakan Social Distancing pada Wabah COVID19 terhadap Kelompok Rentan di Indonesia. Jurnal Kebijakan Kesehatan Indonesia JKKI. 2020; 9(2):61–7. Available from: https://jurnal.ugm.ac.id/jkki/article /view/55575

Qiancheng, X, Jian S, Lingling P, Lei H, Xiaogan J, Weihua L. et al. (2020). Coronavirus disease 2019 in pregnancy. Internat J Infect Dis. 2020;95:376-83. https://doi. org/10.1016/j.ijid.2020.04.065

Rohmah MK, Nurdianto AR. (2020). Corona Virus Disease 2019 ( COVID-19 ) pada Wanita Hamil dan Bayi : Sebuah Tinjauan Literatur. 2020;7(1A):329–36. 3.

Rosyanti L, Hadi I. (2020). Respon imunitas dan badai sitokin severe acute respiratory syndrome coronavirus 2 literatur review. J Kesehat Madani Med. 2020;11(02): 176-201.

Siswosudarmo, R EO. (2016). Obstetri Fisiologi. Yogyakarta: Pustaka Cendikia


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