Extra Virgin Olive Oil meningkatkan ekpresi reseptor estrogen α dan ketebalan Endometrium Rattus Norvegicus yang dipapar Rhodamin B

Ita Noviasari, I Wayan Arsana Wiyasa, Hidayat Sujuti, Eviana Norahmawati
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Abstract


Abstract: Rhodamin B is harmful to the body because it is proven can increase the oxidative stress on various reproductive chain. Rhodamin B contains compounds of chlorine (Cl), is dangerous and halogen compounds are reactive. Damage to the hypothalamus will interfere with the secretion of FSH and LH cause the follicle ripening so distracted that result in a decrease in the hormone estrogen. The hormone estrogen plays an important role in the menstrual cycle and proliferation of the endometrium. This research aimed to prove the effect of Extra Virgin Olive Oil (EVOO) with the expression of estrogen receptors α and endometrial thickness of Rattus norvegicus exposed by rhodamin B. The design used true experimental with an approach of post test only control group design. The research used white rat (Rattus norvegicus wistar strain) as the sample. The results showed that EVOO could become an alternative to prevent oxidative stress due to exposure of rhodamin B.

Keywords: Rhodamin B, Extra Virgin Olive Oil (EVOO), Estrogen receptors α, the thickness of the Endometrium


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References


Arikunto, Suharsimi. 2010. Prosedur Penelitian Suatu Pendekatan Praktek. Jakarta: PT.Rineka Cipta

BPOM, 2005. Pedoman Pertolongan Keracunan Untuk Puskesmas. Bidang Informasi Keracunan Pusat Informasi Obat dan Makanan. Badan POM RI, Jakarta.

Cicelare, S., Lucas, L.J., and Keast, R.S.J. 2010. Biological Activity of phenolic compounds present in virgin olive oil. Molecular Sciences. 11: 458-479

Febrina RGAA., Wiratmini NI., Sudarti NW., 2013. Pengaruh Pemberian Rhodamin B Terhadap Siklus Estrus Mencit (Mus Musculus L) Betina.Jurnal Biologi, XVII(1): 21-23.

Fito,M., Torre, D.R., Albaladejo, M.F., Khymenezt, O., Marrugat, J., and Covas, M.I. 2007. Ann Ist Super Sanita. 43(4):375-381

Guyton AC., dan Hall JE., 2007. Buku Ajar Fisiologi Kedokteran.EGC. Jakarta

Heim KE., Tagliaferro AR., Bobilya DJ., 2002. Flavonoid antioxidant: Chemistry, Metabolism and Structure –Activity Realtionship, Nutr Biochem, 13(10): 572-584.

Maryanti S., Suciati S., Wahyuni ES., Santoso S., Wiyasa IWA., 2014. Rhodamin B Triggers Ovarian Toxicity Through Oxidative Stress. Cukurova Medical Journal, 39(3): 451-457

Muchtadi D., 2012.Pangan Fungsional dan Senyawa Bioaktif.Alfabeta. Bandung.

Mukono HJ., 2005. Toksikologi Lingkungan. Universitas Airlangga, Surabaya.

Sulistina D., 2013.Pengaruh Rhodamin B Terhadap Ekspresi BAX (Bcl-2 Antagonist X) dan BCL-2 (B-cell lymphoma-2) Hypothalamus, FSH (Follicle Stimulating Hormone) dan LH (Luteinizing Hormone) Pada Rattus Norvegicus. Universitas Brawijaya




DOI: 10.26699/jnk.v5i3.ART.p201-206


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